Horizontal concentration equipment
1、 Overview of vacuum concentration equipment
Vacuum concentration equipment is a reaction vessel or device for negative pressure concentration under vacuum. It uses environmental pressure to reduce the boiling point of materials and realize low-temperature and reduced pressure concentration. It is mainly suitable for the concentration and refining of heat sensitive materials (such as alcohol) such as dairy products, biopharmaceuticals and chemical industry. Equipped with vacuum system, the concentration time is short, which can effectively reduce the damage to the effective components of heat sensitive materials. The contact parts between the equipment and materials are made of stainless steel, which has good corrosion resistance and meets the GMP safety and health standards.
2、 Structure of vacuum concentration equipment
The equipment is mainly composed of concentration tank, heater, condenser, vapor-liquid separator, cooler, liquid receiving tank, etc. in addition, it is equipped with heating device, mixing device, jacket or coil, transmission device, shaft seal device, thermal insulation medium, inlet (outlet), support, temperature sensor, CIP interface and other components.
The main equipment of vacuum concentration equipment is made of SUS304 / 316L stainless steel, the inner cylinder wall is mechanically polished or electrolytic mirror polished, the outer cylinder wall is insulated by 304 all welded structure, and the outer surface is treated by mirror or matte; The external connection port of the cylinder adopts sanitary quick opening joint, which is safe and sanitary without dead corner and meets the GMP sanitary standard;
The online control system of vacuum concentration equipment adopts color LCD touch screen + PLC full-automatic control, which can detect and control relevant parameters of concentration process online. The control system includes sterilization interface, parameter setting and correction, data curve, data report, concentrated batch number setting, online animation, alarm device, etc. it can be connected with upper computer, computer and printer to realize remote monitoring, data storage and printing;
In addition, it is also equipped with temperature control device, temperature measuring hole, CIP automatic rotary spray ball, defoamer, baffle, air distributor, temperature sensor, mirror spotlight, liquid level gauge and other equipment, which is convenient for manual operation, simple and reliable.
3、 Structural features of vacuum concentration equipment
1. The main equipment of vacuum concentration equipment is made of SUS304 / 316L stainless steel, with internal and external fine polishing to prevent materials from sticking to the wall, which is not easy to scale, block, stick to the wall and blister, and easy to clean;
2. The equipment has good heat transfer performance and high evaporation efficiency; It adopts push-pull self-locking technology, slag discharge door and stainless steel hard pipe for liquid discharge, which is safe and reliable and does not leak liquid;
3. According to the process needs, various extraction operations such as negative pressure and atmospheric pressure can be realized, and the valve can be switched, which is easy to operate; The vacuum concentration operation is adopted, the evaporation temperature is low, and the agitator can be installed to increase the evaporation speed, prevent material adhesion, reduce foam formation and improve product concentration;
4. The whole machine has compact structure and small floor area; The closed circulation of solvent in the equipment can reduce the above investment, with small investment and high benefit, effectively reduce environmental pollution and meet the requirements of GMP standards.
4、 Quality standard of vacuum concentration equipment
Implementation of design, manufacturing, supervision and inspection:
1. Safety Law of the people's Republic of China on special equipment
2. SFDA drug production quality management specification
3. Tsg21-2016 Supervision Regulation on safety technology of fixed pressure vessels
4. Gb150-2011 pressure vessels
5. Nb / t47015-2011 code for welding of pressure vessels
6. Nb / t47013-2015 nondestructive testing of pressure equipment
7. Hg / t20584-2011 technical requirements for manufacturing steel chemical vessels
8. Heat exchangers (GB / t151-2014)
Vacuum concentration equipment is a reaction vessel or device for negative pressure concentration under vacuum. It uses environmental pressure to reduce the boiling point of materials and realize low-temperature and reduced pressure concentration. It is mainly suitable for the concentration and refining of heat sensitive materials (such as alcohol) such as dairy products, biopharmaceuticals and chemical industry. Equipped with vacuum system, the concentration time is short, which can effectively reduce the damage to the effective components of heat sensitive materials. The contact parts between the equipment and materials are made of stainless steel, which has good corrosion resistance and meets the GMP safety and health standards.
2、 Structure of vacuum concentration equipment
The equipment is mainly composed of concentration tank, heater, condenser, vapor-liquid separator, cooler, liquid receiving tank, etc. in addition, it is equipped with heating device, mixing device, jacket or coil, transmission device, shaft seal device, thermal insulation medium, inlet (outlet), support, temperature sensor, CIP interface and other components.
The main equipment of vacuum concentration equipment is made of SUS304 / 316L stainless steel, the inner cylinder wall is mechanically polished or electrolytic mirror polished, the outer cylinder wall is insulated by 304 all welded structure, and the outer surface is treated by mirror or matte; The external connection port of the cylinder adopts sanitary quick opening joint, which is safe and sanitary without dead corner and meets the GMP sanitary standard;
The online control system of vacuum concentration equipment adopts color LCD touch screen + PLC full-automatic control, which can detect and control relevant parameters of concentration process online. The control system includes sterilization interface, parameter setting and correction, data curve, data report, concentrated batch number setting, online animation, alarm device, etc. it can be connected with upper computer, computer and printer to realize remote monitoring, data storage and printing;
In addition, it is also equipped with temperature control device, temperature measuring hole, CIP automatic rotary spray ball, defoamer, baffle, air distributor, temperature sensor, mirror spotlight, liquid level gauge and other equipment, which is convenient for manual operation, simple and reliable.
3、 Structural features of vacuum concentration equipment
1. The main equipment of vacuum concentration equipment is made of SUS304 / 316L stainless steel, with internal and external fine polishing to prevent materials from sticking to the wall, which is not easy to scale, block, stick to the wall and blister, and easy to clean;
2. The equipment has good heat transfer performance and high evaporation efficiency; It adopts push-pull self-locking technology, slag discharge door and stainless steel hard pipe for liquid discharge, which is safe and reliable and does not leak liquid;
3. According to the process needs, various extraction operations such as negative pressure and atmospheric pressure can be realized, and the valve can be switched, which is easy to operate; The vacuum concentration operation is adopted, the evaporation temperature is low, and the agitator can be installed to increase the evaporation speed, prevent material adhesion, reduce foam formation and improve product concentration;
4. The whole machine has compact structure and small floor area; The closed circulation of solvent in the equipment can reduce the above investment, with small investment and high benefit, effectively reduce environmental pollution and meet the requirements of GMP standards.
4、 Quality standard of vacuum concentration equipment
Implementation of design, manufacturing, supervision and inspection:
1. Safety Law of the people's Republic of China on special equipment
2. SFDA drug production quality management specification
3. Tsg21-2016 Supervision Regulation on safety technology of fixed pressure vessels
4. Gb150-2011 pressure vessels
5. Nb / t47015-2011 code for welding of pressure vessels
6. Nb / t47013-2015 nondestructive testing of pressure equipment
7. Hg / t20584-2011 technical requirements for manufacturing steel chemical vessels
8. Heat exchangers (GB / t151-2014)
